Article
Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cells.
American journal of physiology. Lung cellular and molecular physiology - 1 Oct 2011
Das Aparajita, Acharya Sunil, Gottipati Koteswara Rao, McKnight James B, Chandru Hemakumar, Alcorn Joseph L, Boggaram Vijay
Abstract excerpt
Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) is a homeodomain-containing transcription factor essential for the morphogenesis and differentiation of the lung. In the lung, TTF-1 controls the expression of surfactant proteins that are essential for lung stability and lung host defense. In this study, we identified functionally important transcription factor binding sites in the TTF-1 proximal promoter and...
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