Article
Structural and functional correlates of a mutation in the malignant hyperthermia-susceptible pig ryanodine receptor.
FEBS letters - 13 Apr 1992
Mickelson J R, Knudson C M, Kennedy C F, Yang D I, Litterer L A, Rempel W E, Campbell K P, Louis C F
Abstract excerpt
The skeletal muscle ryanodine receptor of malignant hyperthermia-susceptible (MHS) pigs contains a mutation at residue 615 that is highly correlated with various abnormalities in the regulation of sarcoplasmic reticulum (SR) Ca2+ channel activity. In isolated SR membranes the Arg615 to Cys615 rya...
Topics
- Amino Acid Sequence
- Animals
- Arginine
- Base Sequence
- Calcium Channels
- Cysteine
- Disease Models, Animal
- Malignant Hyperthermia
- Molecular Sequence Data
- Mutation
- Peptide Mapping
- Receptors, Cholinergic
- Ryanodine Receptor Calcium Release Channel
- Sarcoplasmic Reticulum