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Article

Structural and functional correlates of a mutation in the malignant hyperthermia-susceptible pig ryanodine receptor.

FEBS letters - 13 Apr 1992

Mickelson J R, Knudson C M, Kennedy C F, Yang D I, Litterer L A, Rempel W E, Campbell K P, Louis C F

Abstract excerpt

The skeletal muscle ryanodine receptor of malignant hyperthermia-susceptible (MHS) pigs contains a mutation at residue 615 that is highly correlated with various abnormalities in the regulation of sarcoplasmic reticulum (SR) Ca2+ channel activity. In isolated SR membranes the Arg615 to Cys615 ryanodine receptor mutation is now shown to be directly responsible for an altered tryptic peptide map, due to the...

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PMID: 1333412
DOI: 10.1016/0014-5793(92)80208-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Structural and functional correlates of a mutation in the malignant hyperthermia-susceptible pig ryanodine receptor.PMID 1333412Read ↗

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Arg(615)Cys substitution in pig skeletal ryanodine receptors increases activation of single channels by a segment of the skeletal DHPR II-III loop.Semantic proximity Read ↗

Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia.Semantic proximity Read ↗

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