Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia.

doi:10.1038/343559a0

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Article

Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia.

Nature - 8 Feb 1990

MacLennan D H, Duff C, Zorzato F, Fujii J, Phillips M, Korneluk R G, Frodis W, Britt B A, Worton R G

Abstract excerpt

Malignant hyperthermia (MH) is a potentially lethal condition in which sustained muscle contracture, with attendant hypercatabolic reactions and elevation in body temperature, are triggered by commonly used inhalational anaesthetics and skeletal muscle relaxants. In humans, the trait is usually inherited in an autosomal dominant fashion, but in halothane-sensitive pigs with a similar phenotype, inheritance of the...

Topics

Animals
Caffeine
Chromosomes, Human, Pair 19
Female
Genetic Linkage
Halothane
Heterozygote
Homozygote
Humans
Lod Score
Male
Malignant Hyperthermia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Contraction

Mutation

Pedigree

Polymorphism, Restriction Fragment Length

Receptors, Cholinergic

Ryanodine Receptor Calcium Release Channel

Source

Open in PubMed

Identifiers

PMID: 1967823
DOI: 10.1038/343559a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1967823-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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