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Article

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos.

Nature - 15 Oct 1992

Hemmati-Brivanlou A, Melton D A

Abstract excerpt

Activins can induce mesoderm in embryonic explants and have been proposed as the natural inducer in Xenopus. A mutant activin receptor that inhibits activin signalling is used to show that activin is required for the induction of mesoderm in vivo and the patterning of the embryonic body plan. Blocking the activin signal transduction pathway also reveals autonomous induction of a neural marker and unmasks a...

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Source

Identifiers

PMID: 1328888
DOI: 10.1038/359609a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos.PMID 1328888Read ↗

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XTrR-I is a TGFbeta receptor and overexpression of truncated form of the receptor inhibits axis formation and dorsalising activity.Semantic proximity Read ↗

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