A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos.

doi:10.1038/359609a0

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Article

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos.

Nature - 15 Oct 1992

Hemmati-Brivanlou A, Melton D A

Abstract excerpt

Activins can induce mesoderm in embryonic explants and have been proposed as the natural inducer in Xenopus. A mutant activin receptor that inhibits activin signalling is used to show that activin is required for the induction of mesoderm in vivo and the patterning of the embryonic body plan. Blo...

Topics

Activin Receptors
Activins
Animals
Cell Differentiation
Gene Expression
Growth Substances
Inhibins
Mesoderm
Mutagenesis
Phenotype
Receptors, Cell Surface
Signal Transduction
Structure-Activity Relationship
Xenopus laevis

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