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Article

Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos.

Development (Cambridge, England) - 1 Jul 1998

Joseph E M, Melton D A

Abstract excerpt

The Xenopus Vg1 gene, a TGFbeta superfamily member, is expressed as a maternal mRNA localized to prospective endoderm, and mature Vg1 protein can induce both endodermal and mesodermal markers in embryonic cells. Most previous work on embryonic inducers, including activin, BMPs and Vg1, has relied...

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Source

Identifiers

PMID: 9636082
DOI: 10.1242/dev.125.14.2677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9636082-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos.PMID 9636082Read ↗

Induction of dorsal mesoderm by soluble, mature Vg1 proteinSemantic proximity Read ↗

Vg1 has specific processing requirements that restrict its action to body axis patterning centers.Semantic proximity Read ↗

derrière: a TGF-beta family member required for posterior development in Xenopus.Semantic proximity Read ↗

The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo.Semantic proximity Read ↗

Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.Semantic proximity Read ↗

Morpholino knock-down of antivin1 and antivin2 upregulates nodal signaling.Semantic proximity Read ↗

Secretion and mesoderm‐inducing activity of the TGF‐beta‐related domain of Xenopus Vg1.Semantic proximity Read ↗

Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus.Semantic proximity Read ↗

The RNA-binding protein Vg1 RBP is required for cell migration during early neural development.Semantic proximity Read ↗

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos.Semantic proximity Read ↗

Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors.Semantic proximity Read ↗

Bone morphogenetic protein 1 regulates dorsal-ventral patterning in early Xenopus embryos by degrading chordin, a BMP4 antagonist.Semantic proximity Read ↗

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