Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

XTrR-I is a TGFbeta receptor and overexpression of truncated form of the receptor inhibits axis formation and dorsalising activity.

Mechanisms of development - 1 Jul 1998

Mahony D, Weis F M, Massagué J, Gurdon J B

Abstract excerpt

We have previously cloned a type I serine/threonine kinase receptor from Xenopus, namely XTrR-I. We show here that XTrR-I is able to bind and mediate the activity of TGFbeta1, but is unable to mediate response to activin or BMP-4. We have made a truncated receptor construct that can act as a dominant negative mutant receptor, and this can block the activity of TGFbeta2 but not that of activin. Overexpression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Nonmammalian
Share to Gene Deletion
Share to Gene Expression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Mesoderm

Share to Muscles

Share to Mutation

Share to RNA, Messenger

Source

Identifiers

PMID: 9739114
DOI: 10.1016/s0925-4773(98)00092-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

XTrR-I is a TGFbeta receptor and overexpression of truncated form of the receptor inhibits axis formation and dorsalising activity.PMID 9739114Read ↗

A carboxyl-terminal truncated version of the activin receptor mediates activin signals in early Xenopus embryos.Semantic proximity Read ↗

The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling.Semantic proximity Read ↗

The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII.Semantic proximity Read ↗

Embryonic expression and functional analysis of a Xenopus activin receptor.Semantic proximity Read ↗

Role of Thyroid Hormone Receptor in Amphibian Development.Semantic proximity Read ↗

Unliganded thyroid hormone receptor α regulates developmental timing via gene repression in Xenopus tropicalis.Semantic proximity Read ↗

Organ-Specific Requirements for Thyroid Hormone Receptor Ensure Temporal Coordination of Tissue-Specific Transformations and Completion of Xenopus MetamorphosisSemantic proximity Read ↗

Regulation of growth rate and developmental timing by Xenopus thyroid hormone receptor αSemantic proximity Read ↗

Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning.Semantic proximity Read ↗

KDEL tagging: a method for generating dominant-negative inhibitors of the secretion of TGF-beta superfamily proteins.Semantic proximity Read ↗

Xantivin suppresses the activity of EGF-CFC genes to regulate nodal signaling.Semantic proximity Read ↗

The Ror receptor tyrosine kinase family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.