XTrR-I is a TGFbeta receptor and overexpression of truncated form of the receptor inhibits axis formation and dorsalising activity.

doi:10.1016/s0925-4773(98)00092-6

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Article

XTrR-I is a TGFbeta receptor and overexpression of truncated form of the receptor inhibits axis formation and dorsalising activity.

Mechanisms of development - 1 Jul 1998

Mahony D, Weis F M, Massagué J, Gurdon J B

Abstract excerpt

We have previously cloned a type I serine/threonine kinase receptor from Xenopus, namely XTrR-I. We show here that XTrR-I is able to bind and mediate the activity of TGFbeta1, but is unable to mediate response to activin or BMP-4. We have made a truncated receptor construct that can act as a domi...

Topics

Activins
Animals
Body Patterning
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins
Embryo, Nonmammalian
Gene Deletion
Gene Expression
Gene Expression Regulation, Developmental
Inhibins
Mesoderm
Muscles
Mutation
Notochord
RNA, Messenger
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Xenopus

Source

Open in PubMed

Identifiers

PMID: 9739114
DOI: 10.1016/s0925-4773(98)00092-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9739114-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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