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Article

In vivo growth of Epstein-Barr virus transformed B cells with mutations in latent membrane protein 2 (LMP2).

Archives of virology - 1 Jan 1997

Rochford R, Miller C L, Cannon M J, Izumi K M, Kieff E, Longnecker R

Abstract excerpt

Epstein-Barr virus (EBV) causes infectious mononucleosis in adolescents and is associated with malignant B lymphocyte proliferation in AIDS patients, patients undergoing immune suppression for organ transplantation, and SCID mice. In vitro, EBV transformed, latently infected lymphoblastoid B cell...

Topics

Animals
B-Lymphocytes
Cell Division
Cell Line, Transformed
Cell Transformation, Neoplastic
Cell Transformation, Viral
Herpesvirus 4, Human
Humans
Mice
Mice, SCID
Mutation
Viral Matrix Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9170499
DOI: 10.1007/s007050050113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9170499-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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In vivo growth of Epstein-Barr virus transformed B cells with mutations in latent membrane protein 2 (LMP2).PMID 9170499Read ↗

The last seven transmembrane and carboxy-terminal cytoplasmic domains of Epstein-Barr virus latent membrane protein 2 (LMP2) are dispensable for lymphocyte infection and growth transformation in vitro.Semantic proximity Read ↗

LMP1 and EBNA2 constitute a minimal set of EBV genes for transformation of human B cellsSemantic proximity Read ↗

The effects of the Epstein-Barr virus latent membrane protein 2A on B cell function.Semantic proximity Read ↗

Epstein-Barr Virus LMP2A-Induced B-Cell Survival in Two Unique Classes of EμLMP2A Transgenic MiceSemantic proximity Read ↗

Epstein–Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in CarcinogenesisSemantic proximity Read ↗

Mouse model of Epstein–Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative diseaseSemantic proximity Read ↗

Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survivalSemantic proximity Read ↗

Epstein-Barr virus in Burkitt’s lymphoma: A role for latent membrane protein 2ASemantic proximity Read ↗

Latent membrane protein 1 is critical for efficient growth transformation of human B cells by epstein-barr virus.Semantic proximity Read ↗

The latent membrane protein 2 gene of Epstein-Barr virus is important for efficient B cell immortalization.Semantic proximity Read ↗

The only domain which distinguishes Epstein-Barr virus latent membrane protein 2A (LMP2A) from LMP2B is dispensable for lymphocyte infection and growth transformation in vitro; LMP2A is therefore nonessential.Semantic proximity Read ↗

The Effect of Epstein-Barr Virus Latent Membrane Protein 2 Expression on the Kinetics of Early B Cell InfectionSemantic proximity Read ↗

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