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Article

In vivo growth of Epstein-Barr virus transformed B cells with mutations in latent membrane protein 2 (LMP2).

Archives of virology - 1 Jan 1997

Rochford R, Miller C L, Cannon M J, Izumi K M, Kieff E, Longnecker R

Abstract excerpt

Epstein-Barr virus (EBV) causes infectious mononucleosis in adolescents and is associated with malignant B lymphocyte proliferation in AIDS patients, patients undergoing immune suppression for organ transplantation, and SCID mice. In vitro, EBV transformed, latently infected lymphoblastoid B cell lines (LCLs) contain EBV episomes and express nine virus encoded proteins. Six are nuclear proteins (EBNAs) and three...

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Source

Identifiers

PMID: 9170499
DOI: 10.1007/s007050050113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vivo growth of Epstein-Barr virus transformed B cells with mutations in latent membrane protein 2 (LMP2).PMID 9170499Read ↗

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The only domain which distinguishes Epstein-Barr virus latent membrane protein 2A (LMP2A) from LMP2B is dispensable for lymphocyte infection and growth transformation in vitro; LMP2A is therefore nonessential.Semantic proximity Read ↗

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