Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer.

The Journal of biological chemistry - 5 Oct 1992

Naka D, Ishii T, Yoshiyama Y, Miyazawa K, Hara H, Hishida T, Kidamura N

Abstract excerpt

Hepatocyte growth factor (HGF) is a heterodimeric protein consisting of a heavy chain and a light chain held by a disulfide bond. These chains are produced by endoproteolytic processing from a single chain precursor. In this study, we examined whether the processing is a prerequisite for the mitogenic activity of HGF on hepatocytes in primary culture. Single chain HGF was proteolytically converted to the...

Topics

Amino Acid Sequence
Animals
Base Sequence
CHO Cells
Cells, Cultured
Cricetinae
DNA
Electrophoresis, Polyacrylamide Gel
Hepatocyte Growth Factor
Humans
Hydrolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Male

Molecular Sequence Data

Mutation

Protein Processing, Post-Translational

Proto-Oncogene Proteins c-met

Rats

Source

Open in PubMed

Identifiers

PMID: 1328193

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1328193-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer.PMID 1328193Read ↗

Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.Semantic proximity Read ↗

Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa.Semantic proximity Read ↗

In vivo activation of met tyrosine kinase by heterodimeric hepatocyte growth factor molecule promotes angiogenesis.Semantic proximity Read ↗

Molecular characteristics of HGF and the gene, and its biochemical aspects.Semantic proximity Read ↗

Identification of a novel variant hepatocyte growth factor secreted by spleen-derived stromal cells.Semantic proximity Read ↗

Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1.Semantic proximity Read ↗

Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains.Semantic proximity Read ↗

Gene expression and regulation of HGF-SF.Semantic proximity Read ↗

Biological roles of hepatocyte growth factor‑Met signaling from genetically modified animals (Review)Semantic proximity Read ↗

Thinking outside the cell: proteases regulate hepatocyte division.Semantic proximity Read ↗

Isoforms of human HGF and their biological activities.Semantic proximity Read ↗

Genomic organization, chromosomal localization and developmental expression of hepatocyte growth factor-like protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.