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Article

Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1.

The Journal of biological chemistry - 19 Apr 2002

Denda Kimitoshi, Shimomura Takeshi, Kawaguchi Toshiya, Miyazawa Keiji, Kitamura Naomi

Abstract excerpt

Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a Kunitz-type serine protease inhibitor identified as a strong inhibitor of hepatocyte growth factor (HGF) activator and matriptase. HAI-1 is first produced in a membrane-integrated form with two Kunitz domains in its extracellular region, and subsequent ectodomain shedding releases two major secreted forms, one with a single Kunitz domain and one...

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Identifiers

PMID: 11805118
DOI: 10.1074/jbc.M112263200

Genes

HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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