Article
Definition of the HLA-A29 peptide ligand motif allows prediction of potential T-cell epitopes from the retinal soluble antigen, a candidate autoantigen in birdshot retinopathy.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 1996
Boisgerault F, Khalil I, Tieng V, Connan F, Tabary T, Cohen J H, Choppin J, Charron D, Toubert A
Abstract excerpt
The peptide-binding motif of HLA-A29, the predisposing allele for birdshot retinopathy, was determined after acid-elution of endogenous peptides from purified HLA-A29 molecules. Individual and pooled HPLC fractions were sequenced by Edman degradation. Major anchor residues could be defined as glu...
Topics
- Alleles
- Amino Acid Sequence
- Autoantigens
- Autoimmune Diseases
- Binding Sites
- Cell Line
- Consensus Sequence
- Epitopes
- HLA-A Antigens
- Humans
- Ligands
- Molecular Sequence Data
- Peptide Fragments
- Retina