Article
Definition of the HLA-A29 peptide ligand motif allows prediction of potential T-cell epitopes from the retinal soluble antigen, a candidate autoantigen in birdshot retinopathy.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 1996
Boisgerault F, Khalil I, Tieng V, Connan F, Tabary T, Cohen J H, Choppin J, Charron D, Toubert A
Abstract excerpt
The peptide-binding motif of HLA-A29, the predisposing allele for birdshot retinopathy, was determined after acid-elution of endogenous peptides from purified HLA-A29 molecules. Individual and pooled HPLC fractions were sequenced by Edman degradation. Major anchor residues could be defined as glutamate at the second position of the peptide and as tyrosine at the carboxyl terminus. In vitro binding of polyglycine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.