Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A.

doi:10.1101/gad.6.9.1654

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Article

Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A.

Genes & development - 1 Sept 1992

Norris J L, Manley J L

Abstract excerpt

Establishment of dorsal-ventral polarity in the early Drosophila embryo requires a concentration gradient of the maternal morphogen dorsal (dl). This concentration gradient is established by selective nuclear transport of dl so that dl protein is present only in ventral nuclei. The activity of 11 genes is required for dl nuclear localization. One of these genes, Toll, encodes a transmembrane protein that appears...

Topics

Animals
Base Sequence
Biological Transport
Cell Line
Cell Nucleus
Drosophila
Drosophila Proteins
Insect Hormones
Membrane Glycoproteins
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Phosphoproteins

Phosphorylation

Plasmids

Protein Kinases

Receptors, Cell Surface

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 1325392
DOI: 10.1101/gad.6.9.1654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1325392-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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