Heterogeneity of a herpes simplex virus clinical isolate exhibiting resistance to acyclovir and foscarnet.

doi:10.1007/978-1-4615-3462-4_15

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Article

Heterogeneity of a herpes simplex virus clinical isolate exhibiting resistance to acyclovir and foscarnet.

Advances in experimental medicine and biology - 1 Jan 1992

Pelosi E, Hicks K A, Sacks S L, Coen D M

Abstract excerpt

Resistance of herpes simplex virus to acyclovir is a problem of growing clinical importance. Acyclovir-resistance can be due either to mutations in the viral thymidine kinase gene or in the viral DNA polymerase gene. Although clinical resistance has most frequently been associated with thymidine...

Topics

Acyclovir
Animals
Drug Resistance, Microbial
Foscarnet
Genetic Variation
Herpes Simplex
Humans
Phosphonoacetic Acid
Simplexvirus

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