Article
Aberrant splicing of Gs alpha transcript in transformed human astroglial and glioblastoma cell lines.
Nucleic acids research - 25 Aug 1992
Ali I U, Reinhold W, Salvador C, Aguanno S
Abstract excerpt
Alpha subunits of G proteins, which play a vital role in signal transduction, display considerable structural and functional diversity. Point mutations in two forms of alpha subunits, Gs alpha and Gi2 alpha, impairing their GTPase activity, have been detected in endocrine disorders. We report here the presence of truncated Gs alpha transcripts in a human glioblastoma cell line, HS683, and in an SV40-transformed...
Topics
- Amino Acid Sequence
- Astrocytes
- Base Sequence
- Blotting, Western
- Cell Line, Transformed
- GTP-Binding Proteins
- Glioblastoma
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction