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Article

Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene.

Nature - 1 Dec 1994

Wang Z Q, Fung M R, Barlow D P, Wagner E F

Abstract excerpt

The receptor for insulin-like growth factor type 2, also known as the cation-independent mannose-6-phosphate receptor (Igf2/Mpr), is a multifunctional receptor thought to play a role in lysosomal targeting, cell growth and signal transduction. Igf2/Mpr has been mapped to the mouse Tme locus and shown to be an imprinted gene, which further suggests a role in embryonic growth regulation. To define the functions of...

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PMID: 7984240
DOI: 10.1038/372464a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene.PMID 7984240Read ↗

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Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotype.Semantic proximity Read ↗

Paternal repression of the imprinted mouse Igf2r locus occurs during implantation and is stable in all tissues of the post-implantation mouse embryo.Semantic proximity Read ↗

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Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and functionSemantic proximity Read ↗

Regulation of growth and metabolism by imprinted genesSemantic proximity Read ↗

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