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Article

Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis.

American journal of medical genetics - 15 Jul 1992

Tops C M, Vasen H F, van Berge Henegouwen G, Simoons P P, van de Klift H M, van Leeuwen S J, Breukel C, Fodde R, den Hartog Jager F C, Nagengast F M

Abstract excerpt

Turcot syndrome (TS) is a rare genetic disease in which brain tumors occur in association with colonic polyposis. Since Turcot's original description in 1959, there have been disagreements about the mode of inheritance as well as the clinical expression of this condition. Some investigators maint...

Topics

Adenomatous Polyposis Coli
Adolescent
Adult
Alleles
Central Nervous System Neoplasms
Child
Female
Genes, Recessive
Genetic Linkage
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Registries

Syndrome

Source

Identifiers

PMID: 1322639
DOI: 10.1002/ajmg.1320430528

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1322639-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis.PMID 1322639Read ↗

[Turcot syndrome].Semantic proximity Read ↗

Brain tumor-polyposis syndrome: two genetic diseases?Semantic proximity Read ↗

The Molecular Basis of Turcot's SyndromeSemantic proximity Read ↗

A tale of four syndromes: familial adenomatous polyposis, Gardner syndrome, attenuated APC and Turcot syndrome.Semantic proximity Read ↗

Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors.Semantic proximity Read ↗

Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene.Semantic proximity Read ↗

Turcot's syndrome: evidence for linkage to the adenomatous polyposis coli (APC) locus.Semantic proximity Read ↗

A novel APC gene mutation associated with a severe phenotype in a patient with Turcot syndrome.Semantic proximity Read ↗

Non-allelic heterogeneity of familial adenomatous polyposis.Semantic proximity Read ↗

Mutations of the adenomatous polyposis coli and p53 genes in a child with Turcot's syndrome.Semantic proximity Read ↗

Two PMS2 mutations in a Turcot syndrome family with small bowel cancers.Semantic proximity Read ↗

APC and CTNNB1 mutations are rare in sporadic ependymomas.Semantic proximity Read ↗

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