Article
Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene.
Cancer research - 1 Mar 1993
Kikuchi T, Rempel S A, Rutz H P, de Tribolet N, Mulligan L, Cavenee W K, Jothy S, Leduy L, Van Meir E G
Abstract excerpt
The term "Turcot's syndrome" has been used to describe approximatively 55 patients with an association of colonic polyposis and primary neuroepithelial tumors of the central nervous system. The p53 tumor suppressor gene is a possible candidate underlying the syndrome because (a) mutations in the p53 gene are ubiquitous in human cancer, including colon carcinoma and gliomas, and (b) somatic or germ line mutations...
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