Turcot's syndrome: evidence for linkage to the adenomatous polyposis coli (APC) locus.

doi:10.1212/wnl.44.6.1083

Back to search

Article

Turcot's syndrome: evidence for linkage to the adenomatous polyposis coli (APC) locus.

Neurology - 1 Jun 1994

Lasser D M, DeVivo D C, Garvin J, Wilhelmsen K C

Abstract excerpt

OBJECTIVE: To investigate the possibility that neuroepithelial tumors in Turcot's syndrome are caused by pleiotropic mutations in the gene for adenomatous polyposis coli (APC), a tumor-suppressor gene implicated in colonic cancer. METHODS: We studied the inheritance patterns of genetic markers fo...

Topics

Adenomatous Polyposis Coli
Gardner Syndrome
Genetic Linkage
Genetic Markers
Humans
Mutation
Neuroectodermal Tumors, Primitive, Peripheral
Pedigree
Syndrome

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.