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Article

Turcot's syndrome: evidence for linkage to the adenomatous polyposis coli (APC) locus.

Neurology - 1 Jun 1994

Lasser D M, DeVivo D C, Garvin J, Wilhelmsen K C

Abstract excerpt

OBJECTIVE: To investigate the possibility that neuroepithelial tumors in Turcot's syndrome are caused by pleiotropic mutations in the gene for adenomatous polyposis coli (APC), a tumor-suppressor gene implicated in colonic cancer. METHODS: We studied the inheritance patterns of genetic markers for the chromosome 5q21 region in 12 members of a Turcot's syndrome kindred with five affected members. We performed...

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Identifiers

PMID: 8208405
DOI: 10.1212/wnl.44.6.1083

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Turcot's syndrome: evidence for linkage to the adenomatous polyposis coli (APC) locus.PMID 8208405Read ↗

Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis.Semantic proximity Read ↗

[Turcot syndrome].Semantic proximity Read ↗

The Molecular Basis of Turcot's SyndromeSemantic proximity Read ↗

A tale of four syndromes: familial adenomatous polyposis, Gardner syndrome, attenuated APC and Turcot syndrome.Semantic proximity Read ↗

Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors.Semantic proximity Read ↗

Two PMS2 mutations in a Turcot syndrome family with small bowel cancers.Semantic proximity Read ↗

Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.Semantic proximity Read ↗

Phenotypic expression of disease in families that have mutations in the 5' region of the adenomatous polyposis coli gene.Semantic proximity Read ↗

A novel APC gene mutation associated with a severe phenotype in a patient with Turcot syndrome.Semantic proximity Read ↗

Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer.Semantic proximity Read ↗

Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps.Semantic proximity Read ↗

Genetic characterization of the APC locus involved in familial adenomatous polyposis.Semantic proximity Read ↗

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