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Article

Early phenotypic changes of in vitro transformed cells during in vivo progression: possible role of the host innate immunity.

Seminars in cancer biology - 1 Aug 2002

Deichman Galina I

Abstract excerpt

We described the earliest in vivo changes of in vitro transformed cells of various origin manifested in highly-increased H(2)O(2)-catabolizing and PGE(2)-releasing activities. We designate it as [H(2)O(2)(CA) + PGE(S)]-phenotype. It provided tumor cells with resistance to cytotoxicity of Mph and NK cells and correlated with increased tumorigenicity. Used as a functional marker of the early step of in vivo tumor...

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PMID: 12322676
DOI: 10.1016/s1044-579x(02)00018-4

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