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Article

Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins

1 Aug 1992

Abstract excerpt

The E6 oncoproteins encoded by the cancer-associated human papillomaviruses (HPVs) can associate with and promote the degradation of wild-type p53 in vitro. To gain further insight into this process, the ability of HPV-16 E6 to complex with and promote the degradation of mutant forms of p53 was studied. A correlation between binding and the targeted degradation of p53 was established. Mutant p53 proteins that...

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PMID: 1321290
DOI: 10.1128/jvi.66.8.5100-5105.1992

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