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Article

High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector.

Journal of virology - 1 Nov 1993

Varela-Echavarría A, Prorock C M, Ron Y, Dougherty J P

Abstract excerpt

A protocol was designed to measure the forward mutation rate over an entire gene replicated as part of a Moloney murine leukemia virus-based vector. For these studies, the herpes simplex virus thymidine kinase (tk) gene under the control of the spleen necrosis virus U3 promoter was used as target sequence since it allows selection for either the functional or the inactivated gene. Our results indicate that after...

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Identifiers

PMID: 7692080
DOI: 10.1128/JVI.67.11.6357-6364.1993
PMCID: PMC238070

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