High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector.

doi:10.1128/JVI.67.11.6357-6364.1993

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Article

High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector.

Journal of virology - 1 Nov 1993

Varela-Echavarría A, Prorock C M, Ron Y, Dougherty J P

Abstract excerpt

A protocol was designed to measure the forward mutation rate over an entire gene replicated as part of a Moloney murine leukemia virus-based vector. For these studies, the herpes simplex virus thymidine kinase (tk) gene under the control of the spleen necrosis virus U3 promoter was used as target sequence since it allows selection for either the functional or the inactivated gene. Our results indicate that after...

Topics

3T3 Cells
Animals
Base Sequence
DNA Primers
Gene Rearrangement
Genes, Viral
Genes, env
Genetic Vectors
Mice
Molecular Sequence Data
Moloney murine leukemia virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

RNA-Directed DNA Polymerase

Thymidine Kinase

Transduction, Genetic

Viral Structural Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 7692080
DOI: 10.1128/JVI.67.11.6357-6364.1993
PMCID: PMC238070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7692080-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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