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Article

Specificity of nuclear protein binding to a CYP1A1 negative regulatory element.

Biochemical and biophysical research communications - 30 Aug 2002

Nagy Scott R, Denison Michael S

Abstract excerpt

Primary cultures of rat epidermal keratinocytes lose the ability to respond to chemicals with the induction of CYP1A1 gene expression after approximately 15 passages. This repression is mediated by a CT-rich direct repeat negative regulatory DNA (NeRD) element present in the upstream regulatory region of the CYP1A1 gene. Competitive gel retardation analysis using keratinocyte nuclear extracts and mutant NeRD...

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Identifiers

PMID: 12200118
DOI: 10.1016/s0006-291x(02)00945-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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