Article
Theoretical prediction of the gel electrophoretic retardation changes due to point mutations in a tract of SV40 DNA.
Biophysical chemistry - 1 Feb 1992
DeSantis P, Palleschi A, Savino M, Scipioni A
Abstract excerpt
The changes of gel electrophoretic retardation due to single base substitutions in a 173 bp fragment of Sv40 DNA were predicted by using a theoretical model based on conformational energy calculations. As described in previous papers, this model allows successful prediction of the gel electrophoretic retardation of synthetic as well as natural DNAs reported in literature. The experimental retardations related to...
Topics
- Base Sequence
- DNA, Viral
- Electrophoresis
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Simian virus 40