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Article

Structure-activity relationship of the p55 TNF receptor death domain and its lymphoproliferation mutants.

European journal of biochemistry - 1 Mar 2001

De Wilde G, Murray-Rust J, Boone E, Olerenshaw D, McDonald N Q, Ibanez C, Haegeman G, Wollmer A, Federwisch M

Abstract excerpt

Upon stimulation with tumor necrosis factor (TNF), the TNF receptor (TNFR55) mediates a multitude of effects both in normal and in tumor cells. Clustering of the intracellular domain of the receptor, the so-called death domain (DD), is responsible for both the initiation of cell killing and the activation of gene expression. To characterize this domain further, TNFR55 DD was expressed and purified as a...

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Source

Identifiers

PMID: 11231290
DOI: 10.1046/j.1432-1327.2001.02004.x

Genes

TNF
FADD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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