Article
Haplotypic origin of beta-chain genes expressed by human T-cell clones.
Immunogenetics - 1 Jan 1992
Seboun E, Joshi N, Hauser S L
Abstract excerpt
A contribution of allelic variation of T-cell receptor (Tcr) genes to the immune response has not been studied. Here we report that the presence of insertion-deletion-related polymorphisms (IDRP) of the Tcr beta chain (Tcrb) can be utilized to distinguish the parental origin of the gene complex that undergoes rearrangement in individual T-cell clones. Phytohemagglutinin stimulated clones from an individual...
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