Haplotypic origin of beta-chain genes expressed by human T-cell clones.

doi:10.1007/BF00218043

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Article

Haplotypic origin of beta-chain genes expressed by human T-cell clones.

Immunogenetics - 1 Jan 1992

Seboun E, Joshi N, Hauser S L

Abstract excerpt

A contribution of allelic variation of T-cell receptor (Tcr) genes to the immune response has not been studied. Here we report that the presence of insertion-deletion-related polymorphisms (IDRP) of the Tcr beta chain (Tcrb) can be utilized to distinguish the parental origin of the gene complex t...

Topics

Alleles
Chromosome Deletion
Clone Cells
DNA Transposable Elements
Electrophoresis, Gel, Pulsed-Field
Gene Expression
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Haplotypes
Humans
Polymorphism, Genetic
Receptors, Antigen, T-Cell, alpha-beta

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