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Article

Gene editing for latent herpes simplex virus infection reduces viral load and shedding in vivo

13 May 2024

Abstract excerpt

Anti-HSV therapies are only suppressive because they do not eliminate latent HSV present in ganglionic neurons, the source of recurrent disease. We have developed a potentially curative approach against HSV infection, based on gene editing using HSV-specific meganucleases delivered by adeno-associated virus (AAV) vectors. Gene editing performed with two anti-HSV-1 meganucleases delivered by a combination of AAV9,...

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PMID: 38740820
DOI: 10.1038/s41467-024-47940-y

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