Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The pathogenicity of ribonucleotide reductase-null mutants of herpes simplex virus type 1 in mice.

The Journal of infectious diseases - 1 Dec 1991

Yamada Y, Kimura H, Morishima T, Daikoku T, Maeno K, Nishiyama Y

Abstract excerpt

The pathogenicity of ribonucleotide reductase (RR)-null mutants (hrR3 and ICP6 delta) of herpes simplex virus (HSV) type 1 was studied after intracerebral and corneal inoculation in newborn and adult ICR mice. ICP6 delta failed to replicate in brains of mice greater than or equal to 8 days old but exhibited significant virulence for newborn mice as a result of viral replication in the brains. The RR- and a...

Topics

Animals
Animals, Newborn
Brain
DNA, Viral
Eye
Male
Mice
Mice, Inbred ICR
Mutation
Polymerase Chain Reaction
Ribonucleotide Reductases
Simplexvirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trigeminal Ganglion

Vero Cells

Virulence

Virus Replication

Source

Identifiers

PMID: 1659596
DOI: 10.1093/infdis/164.6.1091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1659596-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The pathogenicity of ribonucleotide reductase-null mutants of herpes simplex virus type 1 in mice.PMID 1659596Read ↗

Deletion of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo.Semantic proximity Read ↗

Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced ReactivationSemantic proximity Read ↗

The herpes simplex virus type 1 ribonucleotide reductase is required for acute retinal disease.Semantic proximity Read ↗

Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants.Semantic proximity Read ↗

Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo.Semantic proximity Read ↗

Histopathological responses in the CNS following inoculation with a non-neurovirulent mutant (1716) of herpes simplex virus type 1 (HSV 1): relevance for gene and cancer therapy.Semantic proximity Read ↗

A herpes simplex type 1 ICPO deletion mutant demonstrates diminished pathogenicity during acute ocular infection in different host animals.Semantic proximity Read ↗

Toxicity and neuronal infection of a HSV-1 ICP34.5 mutant in nude mice.Semantic proximity Read ↗

Deletion of the Herpes simplex 1 internal repeat sequences affects pathogenicity in the mouse.Semantic proximity Read ↗

Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation in mice.Semantic proximity Read ↗

Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models.Semantic proximity Read ↗

Optimized Viral Dose and Transient Immunosuppression Enable Herpes Simplex Virus ICP0-Null Mutants To Establish Wild-Type Levels of Latency In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.