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Article

Polymorphisms of the NADPH oxidase P22PHOX gene in a Caucasian population with intracranial aneurysms.

Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2003

Krex Dietmar, Ziegler Andreas, König Inke R, Schackert Hans K, Schackert Gabriele

Abstract excerpt

BACKGROUND: Vascular remodeling generated by reactive oxygen species contributes to aneurysm formation. The NADPH oxidase system is a major source of superoxide anion not only in phagocytes, but also in endothelial and vascular smooth muscle cells. Polymorphisms of p22phox, an essential component of the NADPH oxidase system, are found to be associated with atherosclerosis, while a recent study found a significant...

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PMID: 13130177
DOI: 10.1159/000072558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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