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Article

Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1.

Virology - 15 Jan 2018

Mesalam Ahmed Atef, Desombere Isabelle, Farhoudi Ali, Van Houtte Freya, Verhoye Lieven, Ball Jonathan, Dubuisson Jean, Foung Steven K H, Patel Arvind H, Persson Mats A A, Leroux-Roels Geert, Meuleman Philip

Abstract excerpt

Monoclonal antibodies (mAbs) targeting the hepatitis C virus (HCV) envelope have been raised mainly against envelope protein 2 (E2), while the antigenic epitopes of envelope protein 1 (E1) are not fully identified. Here we describe the detailed characterization of a human mAb, designated A6, generated from an HCV genotype 1b infected patient. ELISA results showed reactivity of mAb A6 to full-length HCV E1E2 of...

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Share to Antibodies, Monoclonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29128754
DOI: 10.1016/j.virol.2017.10.019
PMCID: PMC5784761

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