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A herpes simplex virus 1 (McKrae) mutant lacking the glycoprotein K gene is unable to infect via neuronal axons and egress from neuronal cell bodies.

mBio - 1 Jan 2012

David Andrew T, Saied Ahmad, Charles Anu, Subramanian Ramesh, Chouljenko Vladimir N, Kousoulas Konstantin G

Abstract excerpt

UNLABELLED: We have shown that the herpes simplex virus 1 (HSV-1) gK gene is essential for efficient replication and spread in the corneal epithelium and trigeminal ganglion neuroinvasion in mice (A. T. David, A. Baghian, T. P. Foster, V. N. Chouljenko, and K. G. Kousoulas, Curr. Eye Res. 33:455-467, 2008). To further investigate the role of gK in neuronal infection, we utilized a microfluidic chamber system...

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Identifiers

PMID: 22829677
DOI: 10.1128/mBio.00144-12
PMCID: PMC3413403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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