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Epidermal Growth Factor Receptor Gene Amplification and Protein Expression in Glioblastoma Multiforme

1 Mar 2006

Abstract excerpt

Epidermal growth factor receptor (EGFR) overexpression occurs in a significant percentage of cases of glioblastoma multiforme (GBM), and amplification has been found in approximately 40% of these neoplasms. Controversy exists as to the prognostic significance of EGFR gene amplification: some reports have indicated that amplification is associated with a poor prognosis, while other authors have reported no...

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PMID: 16540738
DOI: 10.1097/01.pai.0000159772.73775.2e

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