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Article

Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway

17 Apr 2006

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Share to Bladder and Urothelial Cancer Treatments
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Share to Epigenetics and DNA Methylation

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 16619045
DOI: 10.1038/sj.onc.1209513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathwayPMID 16619045Read ↗

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cellsSemantic proximity Read ↗

Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expressionSemantic proximity Read ↗

The New Immortalized Uroepithelial Cell Line HBLAK Contains Defined Genetic Aberrations Typical of Early Stage Urothelial TumorsSemantic proximity Read ↗

Immortalisation of human urothelial cellsSemantic proximity Read ↗

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.Semantic proximity Read ↗

Genes Involved in Differentiation, Stem Cell Renewal, and Tumorigenesis Are Modulated in Telomerase-Immortalized Human Urothelial CellsSemantic proximity Read ↗

Genetic and Epigenetic Changes in Human Epithelial Cells Immortalized by TelomeraseSemantic proximity Read ↗

Immortalization of human small airway epithelial cells by ectopic expression of telomeraseSemantic proximity Read ↗

Use of exogenous hTERT to immortalize primary human cellsSemantic proximity Read ↗

An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor.Semantic proximity Read ↗

hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristicsSemantic proximity Read ↗

Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.Semantic proximity Read ↗

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