Article
Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics.
Nature - 16 Jan 1992
Jorgensen J L, Esser U, Fazekas de St Groth B, Reay P A, Davis M M
Abstract excerpt
To test models of T-cell recognition, mice transgenic for T-cell receptor alpha or beta chain have been immunized with variant peptides that force changes in the resulting T-cell response. In particular, charge substitutions on the peptide often elicit reciprocal charges in the junctional (CDR3)...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- Binding, Competitive
- CD3 Complex
- Columbidae
- Cytochrome c Group
- Genetic Variation
- Kinetics
- Lymph Nodes
- Lymphocyte Activation
- Lymphocytes
- Macromolecular Substances
- Major Histocompatibility Complex
- Mice
- Mice, Transgenic
- Models, Structural