Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics.

Nature - 16 Jan 1992

Jorgensen J L, Esser U, Fazekas de St Groth B, Reay P A, Davis M M

Abstract excerpt

To test models of T-cell recognition, mice transgenic for T-cell receptor alpha or beta chain have been immunized with variant peptides that force changes in the resulting T-cell response. In particular, charge substitutions on the peptide often elicit reciprocal charges in the junctional (CDR3) sequences of T-cell receptor V alpha or V beta chains, indicating direct T-cell receptor-peptide contact, and allowing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kinetics

Share to Lymphocyte Activation

Share to Lymphocytes

Share to Mice, Transgenic

Source

Identifiers

PMID: 1309938
DOI: 10.1038/355224a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics.PMID 1309938Read ↗

Transgenic mice with a diverse human T cell antigen receptor repertoireSemantic proximity Read ↗

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.Semantic proximity Read ↗

Subtle affinity-enhancing mutations in a myelin oligodendrocyte glycoprotein-specific TCR alter specificity and generate new self-reactivity.Semantic proximity Read ↗

Recognition of a specific self-peptide: self-MHC class II complex is critical for positive selection of thymocytes expressing the D10 TCR.Semantic proximity Read ↗

Germline T cell receptor exchange results in physiological T cell development and functionSemantic proximity Read ↗

The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.Semantic proximity Read ↗

The somatically generated T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptorSemantic proximity Read ↗

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.Semantic proximity Read ↗

Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.Semantic proximity Read ↗

Optimisation of T cell receptors using in vivo recombination and selectionSemantic proximity Read ↗

Hyper-reactive cloned mice generated by direct nuclear transfer of antigen-specific CD4+ T cells.Semantic proximity Read ↗

T antigen transgenic mouse modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.