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Article

Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998

Ghendler Y, Teng M K, Liu J H, Witte T, Liu J, Kim K S, Kern P, Chang H C, Wang J H, Reinherz E L

Abstract excerpt

The T lineage repertoire is shaped by T cell receptor (TCR)-dependent positive and negative thymic selection processes. Using TCR-transgenic (N15tg) beta2-microglobulin-deficient (beta2m-/-) RAG-2(-/-) H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to Kb, we identified a single weak agonist peptide variant V4L (L4) inducing phenotypic and functional T cell maturation. The cognate VSV8 peptide, in...

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Identifiers

PMID: 9707600
DOI: 10.1073/pnas.95.17.10061
PMCID: PMC21461

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Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.PMID 9707600Read ↗

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