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Article

Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice.

The Journal of clinical investigation - 1 Sept 2003

Wu Xue-Bin, Li Yanan, Schneider Adina, Yu Wanqin, Rajendren Gopalan, Iqbal Jameel, Yamamoto Matsuo, Alam Mohammad, Brunet Lisa J, Blair Harry C, Zaidi Mone, Abe Etsuko

Abstract excerpt

We describe the effects of the overexpression of noggin, a bone morphogenetic protein (BMP) inhibitor, on osteoblast differentiation and bone formation. Cells of the osteoblast and chondrocyte lineages, as well as bone marrow macrophages, showed intense beta-gal histo- or cytostaining in adult noggin+/- mice that had a LacZ transgene inserted at the site of noggin deletion. Despite identical BMP levels, however,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12975477
DOI: 10.1172/JCI15543
PMCID: PMC193662

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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