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Article

A comparison of directed evolution approaches using the beta-glucuronidase model system.

Journal of molecular biology - 26 Sept 2003

Rowe Lori A, Geddie Melissa L, Alexander Omar B, Matsumura Ichiro

Abstract excerpt

Protein engineers can alter the properties of enzymes by directing their evolution in vitro. Many methods to generate molecular diversity and to identify improved clones have been developed, but experimental evolution remains as much an art as a science. We previously used DNA shuffling (sexual r...

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Identifiers

PMID: 12972256
DOI: 10.1016/s0022-2836(03)00972-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12972256-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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