Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure-Guided Directed Evolution of Glycosidases: A Case Study in Engineering a Blood Group Antigen-Cleaving Enzyme.

Methods in enzymology - 1 Jan 2017

Kwan David H

Abstract excerpt

Directed evolution is an incredibly powerful strategy for engineering enzyme function. Applying this approach to glycosidases offers enormous potential for the development of highly specialized tools in chemical glycobiology. Performing enzyme directed evolution requires the generation, by random mutagenesis, of mutant libraries from which large numbers of variant enzymes must be screened in high-throughput...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Group Antigens
Share to Directed Molecular Evolution
Share to Gene Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycoside Hydrolases

Share to Molecular Structure

Share to Mutagenesis, Site-Directed

Share to Protein Conformation

Share to Protein Engineering

Source

Identifiers

PMID: 28935105
DOI: 10.1016/bs.mie.2017.06.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure-Guided Directed Evolution of Glycosidases: A Case Study in Engineering a Blood Group Antigen-Cleaving Enzyme.PMID 28935105Read ↗

Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution.Semantic proximity Read ↗

Structure-based enzyme engineering and its impact on in vitro glycorandomization.Semantic proximity Read ↗

Discovery of superior enzymes by directed molecular evolution.Semantic proximity Read ↗

Strategy and success for the directed evolution of enzymes.Semantic proximity Read ↗

Advances in laboratory evolution of enzymes.Semantic proximity Read ↗

Advances in directed protein evolution by recursive genetic recombination: applications to therapeutic proteins.Semantic proximity Read ↗

Directed Evolution of Protein Catalysts.Semantic proximity Read ↗

Investigating and Engineering Enzymes by Genetic SelectionSemantic proximity Read ↗

Using experimental evolution to probe molecular mechanisms of protein function.Semantic proximity Read ↗

Directed enzyme evolution: beyond the low-hanging fruit.Semantic proximity Read ↗

Beyond antibody engineering: directed evolution of alternative binding scaffolds and enzymes using yeast surface displaySemantic proximity Read ↗

The diversity challenge in directed protein evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.