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Article

Mutation frequency of PRKAR1B and the major familial dementia genes in a Dutch early onset dementia cohort.

Journal of neurology - 1 Nov 2014

Cohn-Hokke P E, Wong T H, Rizzu P, Breedveld G, van der Flier W M, Scheltens P, Baas F, Heutink P, Meijers-Heijboer E J, van Swieten J C, Pijnenburg Y A L

Abstract excerpt

Genetic factors are important in all forms of dementia, especially in early onset dementia. The frequency of major gene defects in dementia has not been investigated in the Netherlands. Furthermore, whether the recently in a FTD family identified PRKAR1B gene is associated with an Alzheimer's disease (AD) like phenotype, has not been studied. With this study, we aimed to investigate the mutation frequency of the...

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Source

Identifiers

PMID: 25108559
DOI: 10.1007/s00415-014-7456-y

Genes

GRN
MAPT
PSEN1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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