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Article

High-performance liquid chromatography-mass spectrometry analysis of diltiazem and 11 of its phase I metabolites in human plasma.

Journal of pharmaceutical and biomedical analysis - 19 Sept 2003

Molden Espen, Helen Bøe Grethe, Christensen Hege, Reubsaet Leon

Abstract excerpt

The aim of the present work was to develop a high-performance liquid chromatography-mass spectrometry method for analysis of diltiazem (DTZ) and metabolites in human plasma after single dose administration (120 mg). Human plasma samples (1 ml) were cleaned up by a solid phase extraction procedure (C18 cartridges) using codeine as an internal standard. Reconstituted extracts were separated on a reversed-phase C8...

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PMID: 12972092
DOI: 10.1016/s0731-7085(03)00259-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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