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Article

Pharmacokinetics of desipramine HCl when administered with cinacalcet HCl.

European journal of clinical pharmacology - 1 Feb 2007

Harris Robert Z, Salfi Margaret, Posvar Ed, Hoelscher David, Padhi Desmond

Abstract excerpt

OBJECTIVE: In vitro work has demonstrated that cinacalcet is a strong inhibitor of cytochrome P450 isoenzyme (CYP) 2D6. The purpose of this study was to evaluate the effect of cinacalcet on CYP2D6 activity, using desipramine as a probe substrate, in healthy subjects. METHODS: Seventeen subjects who were genotyped as CYP2D6 extensive metabolizers were enrolled in this randomized, open-label, crossover study to...

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Identifiers

PMID: 16680561
DOI: 10.1007/s00228-006-0129-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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