Article
Association of CYP3A4 genotype with treatment-related leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 27 Oct 1998
Felix C A, Walker A H, Lange B J, Williams T M, Winick N J, Cheung N K, Lovett B D, Nowell P C, Blair I A, Rebbeck T R
Abstract excerpt
Epipodophyllotoxins are associated with leukemias characterized by translocations of the MLL gene at chromosome band 11q23 and other translocations. Cytochrome P450 (CYP) 3A metabolizes epipodophyllotoxins and other chemotherapeutic agents. CYP3A metabolism generates epipodophyllotoxin catechol a...
Topics
- Adolescent
- Antineoplastic Agents, Phytogenic
- Child
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- DNA-Binding Proteins
- Ethnicity
- Female
- Histone-Lysine N-Methyltransferase
- Humans