Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-dependent time course of lymphocyte beta 2-adrenergic receptor down-regulation.

Clinical pharmacology and therapeutics - 1 Sept 2003

Bruck Heike, Leineweber Kirsten, Beilfuss Anja, Weber Melanie, Heusch Gerd, Philipp Thomas, Brodde Otto-Erich

Abstract excerpt

BACKGROUND: Volunteers homozygous for Glu27 beta(2)-adrenergic receptor (beta(2)AR) polymorphism have delayed onset of agonist-induced desensitization of cardiac beta(2)AR responses. METHODS AND RESULTS: To determine whether this can also be demonstrated for Glu27Glu beta(2)AR natively expressed in circulating lymphocytes, we assessed the effects of 2 weeks of oral treatment with 3 x 5 mg/d terbutaline on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenergic beta-Agonists
Share to Adrenergic beta-Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP

Share to Down-Regulation

Share to Heart Rate

Share to Lymphocytes

Share to Myocardial Contraction

Share to Receptors, Adrenergic, beta-2

Source

Identifiers

PMID: 12966369
DOI: 10.1016/S0009-9236(03)00188-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-dependent time course of lymphocyte beta 2-adrenergic receptor down-regulation.PMID 12966369Read ↗

The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo.Semantic proximity Read ↗

Differential desensitization of homozygous haplotypes of the beta2-adrenergic receptor in lymphocytes.Semantic proximity Read ↗

Polymorphism of the beta(2)-adrenergic receptor gene and desensitization in human airway smooth muscle.Semantic proximity Read ↗

Thr164Ile polymorphism of the human beta2-adrenoceptor exhibits blunted desensitization of cardiac functional responses in vivo.Semantic proximity Read ↗

Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension.Semantic proximity Read ↗

The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization.Semantic proximity Read ↗

Beta2-adrenergic receptor genotype-related changes in cAMP levels in peripheral blood mononuclear cells after multiple-dose oral procaterol.Semantic proximity Read ↗

Effects of genetic polymorphism on ex vivo and in vivo function of beta2-adrenoceptors in asthmatic patients.Semantic proximity Read ↗

Response to catecholamine stimulation of polymorphisms of the beta-1 and beta-2 adrenergic receptors.Semantic proximity Read ↗

Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells.Semantic proximity Read ↗

beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals.Semantic proximity Read ↗

Genotype related differences in beta2 adrenergic receptor density and cardiac function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.