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Article

Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.

Human molecular genetics - 1 Nov 2003

Morabia Alfredo, Cayanis Eftihia, Costanza Michael C, Ross Barbara M, Flaherty Maria Sol, Alvin Gabriela B, Das Kamna, Gilliam T Conrad

Abstract excerpt

This study explored the genetic basis of the combination of extreme blood levels of HDL-C and LDL-C, a well-studied endophenotype for CVD, which has several attractive features as a target for genetic analysis: (1) the trait is moderately heritable; (2) non-genetic risk factors account for a significant but still limited portion of the phenotypic variance; (3) it is known to be moderated by a number of gene...

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Identifiers

PMID: 12966036
DOI: 10.1093/hmg/ddg314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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