Article
Evidence of a polygenic origin of extreme high-density lipoprotein cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2013
Motazacker Mohammad Mahdi, Peter Jorge, Treskes Marco, Shoulders Carol C, Kuivenhoven Jan Albert, Hovingh G Kees
Abstract excerpt
OBJECTIVE: There are several known monogenic causes of high and low high-density lipoprotein cholesterol (HDL-C) levels, but traditional sequencing studies have had limited success in identifying mutations in the majority of individuals with extreme HDL-C levels. The aim of this study was to assess the power of a targeted high-throughput sequencing strategy to elucidate the genetic basis of extreme HDL-C...
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