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Article

Polygenic determinants in extremes of high-density lipoprotein cholesterol.

Journal of lipid research - 1 Nov 2017

Dron Jacqueline S, Wang Jian, Low-Kam Cécile, Khetarpal Sumeet A, Robinson John F, McIntyre Adam D, Ban Matthew R, Cao Henian, Rhainds David, Dubé Marie-Pierre, Rader Daniel J, Lettre Guillaume, Tardif Jean-Claude, Hegele Robert A

Abstract excerpt

HDL cholesterol (HDL-C) remains a superior biochemical predictor of CVD risk, but its genetic basis is incompletely defined. In patients with extreme HDL-C concentrations, we concurrently evaluated the contributions of multiple large- and small-effect genetic variants. In a discovery cohort of 255 unrelated lipid clinic patients with extreme HDL-C levels, we used a targeted next-generation sequencing panel to...

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Identifiers

PMID: 28870971
DOI: 10.1194/jlr.M079822
PMCID: PMC5665671

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