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Article

Model mice for Presbyterian hemoglobinopathy (Asn(beta108)-->Lys) confer hemolytic anemia with altered oxygen affinity and instability of Hb.

Biochemical and biophysical research communications - 26 Jul 2002

Suzuki Yo-ichi, Shimizu Takahiko, Sakai Hiromi, Tamaki Masakatsu, Koizumi Ken ichi, Kuriyama Takayuki, Tsuchida Eishun, Koseki Haruhiko, Shirasawa Takuji

Abstract excerpt

Hb Presbyterian is a variant hemoglobin that carries Lys at Asn-108 of beta-globin. This variant Lys(beta108) residue enhances the stability of Hb in the deoxy-state, conferring the low affinity for oxygen-binding in vitro. In the present study, we generated mutant mice carrying the Presbyterian mutation (Asn(beta108)-->Lys) at the beta-globin locus by a targeted knock-in strategy. Heterozygous mice showed the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 12127975
DOI: 10.1016/s0006-291x(02)00752-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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