Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors

3 Jul 2003

Abstract excerpt

We report that CYP3a13 gene, located on mouse chromosome 5, spans 27.5 Kb and contains 13 exons. The transcription start site is 35 bp upstream of the coding region and results in a 109 bp 5' untranslated region. CYP3a13 promoter shows putative binding sites for retinoid X receptor, pregnane X receptor, and estrogen receptor. CYP3a13 shows a broad tissue distribution with predominant expression in liver. Although...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Estrogen and related hormone effects
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12958193
DOI: 10.1096/fj.02-1004fje

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptorsPMID 12958193Read ↗

Role of hepatocyte nuclear factor 3γ in the expression of human CYP2C genesSemantic proximity Read ↗

Impact of sex and pregnancy on hepatic CYP3A4 expression and activity in a humanized mouse modelSemantic proximity Read ↗

Transcriptional Regulation and Expression of CYP3A4 in HepatocytesSemantic proximity Read ↗

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A geneSemantic proximity Read ↗

Inherent sex‐dependent regulation of human hepatic CYP3A5Semantic proximity Read ↗

Statin regulation of CYP3A4 and CYP3A5 expression.Semantic proximity Read ↗

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during EvolutionSemantic proximity Read ↗

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during EvolutionSemantic proximity Read ↗

Regulation of<i>CYP3A</i>Gene Transcription by the Pregnane X ReceptorSemantic proximity Read ↗

Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.Semantic proximity Read ↗

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.Semantic proximity Read ↗

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.