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Article

Statin regulation of CYP3A4 and CYP3A5 expression.

Pharmacogenomics - 1 Jun 2009

Willrich Maria Alice Vieira, Hirata Mario Hiroyuki, Hirata Rosario Dominguez Crespo

Abstract excerpt

CYP3A4 and CYP3A5 are cytochrome P450 enzymes that are highly expressed in the liver and gut and metabolize endogenous compounds and xenobiotics. Statins are cholesterol-lowering drugs that are extensively metabolized by CYP3A4 and CYP3A5. The bioavailability of statins is affected by CYP3A4 and CYP3A5 and glucuronidases metabolism as well as uptake and efflux transporters that affect drug disposition. CYP3A4 and...

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Share to Cytochrome P-450 CYP3A
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 19530969
DOI: 10.2217/pgs.09.42

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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