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Detection of mutation in transgenic CHO cells using green fluorescent protein as a reporter.

Mutation research - 27 Jun 2002

Dobrovolsky Vasily N, McGarrity Lynda J, Morris Suzanne M, Heflich Robert H

Abstract excerpt

A novel approach was developed for rapidly estimating the frequency of specific mutations in genetically engineered Chinese hamster ovary (CHO) cells. We designed double-transgenic CHO cell lines that contain a transgene consisting of the sequence coding for green fluorescent protein under the control of a tetracycline (Tet) responsive promoter and a second transgene coding for the constitutively expressed Tet...

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PMID: 12063067
DOI: 10.1016/s1383-5718(02)00072-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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