Article
Mutant p53 product in patients with stage III cervical cancer.
Anticancer research - 1 Jan 2000
Gitsch G, Kainz C, Joura E, Breitenecker G
Abstract excerpt
Mutations in the p53 gene stimulate cell division. In our study we assessed the prognostic value of mutant p53 overexpression in cervical cancer stage FIGO III detected by immunohistochemistry. In 43 tissue specimens were detected p53 overexpression in 20 cases. Mean survival time was 36.4 (SE +/- 7.66) months in the p53 protein positive group. The group without p53 overexpression showed a mean survival time of...
Topics
- Female
- Gene Expression
- Genes, p53
- Humans
- Immunohistochemistry
- Middle Aged
- Mutation
- Neoplasm Staging
- Open Reading Frames
- Prognosis
- Survival Analysis
- Tumor Suppressor Protein p53
