Article
The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques.
Virology - 1 Sept 2003
Singh Dinesh K, Griffin Darcy M, Pacyniak Erik, Jackson Mollie, Werle Michael J, Wisdom Bo, Sun Francis, Hout David R, Pinson David M, Gunderson Robert S, Powers Michael F, Wong Scott W, Stephens Edward B
Abstract excerpt
The simian-human immunodeficiency virus (SHIV)/ macaque model for human immunodeficiency virus type 1 has become a useful tool to assess the role of Vpu in lentivirus pathogenesis. In this report, we have mutated the two phosphorylated serine residues of the HIV-1 Vpu to glycine residues and have reconstructed a SHIV expressing this nonphosphorylated Vpu (SHIV(S52,56G)). Expression studies revealed that this...
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